Iodide entry into the thyroid follicular cells is the first and rate-limiting step in the process of thyroid hormone biosynthesis. Transport of iodide across the basolateral membrane of follicular cells from the blood/interstitial fluid side to the cytoplasmic space is accomplished by:

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Physiology Test Question

Iodide entry into the thyroid follicular cells is the first and rate-limiting step in the process of thyroid hormone biosynthesis. Transport of iodide across the basolateral membrane of follicular cells from the blood/interstitial fluid side to the cytoplasmic space is accomplished by:

	(A) simple diffusion of iodide through the basolateral membrane
	(B) the activity of the Na⁺/iodide symporter (NIS)
	(C) Cl⁻/I⁻ exchange
	(D) movement of iodide into the cell down its electrochemical gradient through an iodide channel in the basolateral membrane
	(E) All of the above

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Posted: Tuesday, January 20, 2015