Glossary of Physiology Terms
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5 glossary search results for:
voltage gated k channel
Definition:
The Hodgkin cycle represents a positive feedback loop in neurons, where an initial membrane depolarization from the resting value (∼ −70 mV) to the threshold value (∼ −50 mV) leads to rapid depolarization of the membrane potential to approach the equilibrium potential for Na
+ (
VNa ≈ +60 mV). The voltage-gated Na
+ channels of neurons are responsible for the Hodgkin cycle.
See the
figure depicting the Hodgkin cycle.
See also:
Important Features of the Neuronal Action Potential
Definition:
Lidocaine is a local anesthetic and an antiarrhythmic drug. It is a commonly used local anesthetic for minor surgery and in dental procedures. Lidocaine is also used topically to relieve itching, burning, and pain from skin inflammations.
Lidocaine's mechanism of action is to block fast voltage-gated Na
+ channels of neurons and cardiac myocytes.
Other names used for lidocaine are xylocaine and lignocaine.
See also:
Pharmacological Inhibition of Na+ and K+ ChannelsOther resources:
Lidocaine (Wikipedia)
Abbreviation:
TEA
Definition:
An inhibitor of voltage-gated potassium (K
+) channels.
TEA is a quaternary ammonium
cation (positively charged ion). It is also commonly used as a cation replacement for sodium (Na
+) in physiological buffers used in ion replacement experiments.
See also:
Pharmacological Inhibition of Na+ and K+ Channels
Posted: Sunday, March 31, 2013
Last updated: Friday, August 28, 2015