Glossary of Physiology Terms
There are
6 glossary search results for:
bio chemical
Definition:
Refers to the concentration gradient of an ion or molecule. The concentration gradient may exist across a biological membrane, where the concentration is higher on one side of the membrane compared to the other side. Concentration gradient may also exist in a solution without an apparent barrier separating the area of higher concentration from the area of lower concentration. In both cases, the free energy that results from the concentration difference drives the movement of the ion/molcule from the area of higher concentration to the area of lower concentration. In free solution, the ion/molecule simply diffuses down its gradient. Movement across a biological membrane is more complicated and is a function of lipid solubility of the ion/molecule as well as the presence of channels or transport proteins that can allow the ion/molecule to cross the membrane (see
Lipid Bilayer Permeability and
Summary of Membrane Transport Processes).
Related glossary terms/phrases:
Electrical gradientElectrochemical gradient
Definition:
A type of
secondary active transport across a biological membrane in which a transport protein couples the movement of an ion (usually Na
+ or H
+) down its electrochemical gradient to the movement of another ion or molecule against a concentration or electrochemical gradient. The ion moving down its electrochemical gradient is referred to as the driving ion. The ion/molecule being transported against a chemical or electrochemical gradient is referred to as the driven ion/molecule.
In cotransport, the direction of transport is the same for both the driving ion and driven ion/molecule (into the cell or out of the cell).
An example is the Na
+/glucose cotransporter (SGLT), which couples the movement of Na
+ into the cell down its electrochemical gradient to the movement of glucose into the cell against its concentration gradient.
Cotransport is also commonly referred to as
symport.
Transport proteins that are involved in this type of transport are referred to as cotransporters or symporters.
See:
SymportRelated glossary terms/phrases:
Secondary active transportExchangeSee also:
Lecture notes on
Secondary Active Transport
Definition:
A type of
secondary active transport across a biological membrane in which a transport protein couples the movement of an ion (usually Na
+ or H
+) down its electrochemical gradient to the movement of another ion or molecule against a concentration or electrochemical gradient. The ion moving down its electrochemical gradient is referred to as the driving ion. The ion/molecule being transported against a chemical or electrochemical gradient is referred to as the driven ion/molecule.
In exchange, the driving ion and the driven ion/molecule are transported across the biological membrane in opposite directions.
An example is the Na
+/Ca
2+ exchanger (NCX), which couples the movement of 3 Na
+ ions into the cell down its electrochemical gradient to the movement of 1 Ca
2+ ion out of the cell against its electrochemical gradient.
Exchange is also commonly referred to as
antiport.
Transport proteins that are involved in this type of transport are referred to as exchangers or antiporters.
See:
AntiportRelated glossary terms/phrases:
Secondary active transportCotransportSee also:
Lecture notes on
Secondary Active Transport
Definition:
Refers to the ability of the thyroid gland to accumulate iodide (I
−) against a steep electrochemical gradient. While the iodide concentration in plasma and interstitial fluid is approximately 300 nL, iodide concentration in the cytoplasm of thyroid follicular cells, as well as the lumen of thyroid follicles can be many folds higher. The protein that enables iodide transport into the thyroid gland against an electrochemical gradient is the Na
+/iodide symporter (NIS), which is located in the basolateral membrane of thyroid follicular cells. Within the lumen of thyroid follicles, iodide is incorporated into the tyrosine residues of thyroglobulin during thyroid hormone biosynthesis, hence, allowing very high iodide concentrations in the colloid.
Definition:
Secondary active transport is a type of active transport across a biological membrane in which a transport protein couples the movement of an ion (typically Na
+ or H
+) down its electrochemical gradient to the movement of another ion or molecule against a concentration or electrochemical gradient. The ion moving down its electrochemical gradient is referred to as the driving ion. The ion/molecule being transported against a chemical or electrochemical gradient is referred to as the driven ion/molecule.
This transport process is referred to as
active transport because the driven ion/molecule is transported against a concentration or electrochemical gradient. It is referred to as
secondary active transport because no ATP hydrolysis is involved in this process (as opposed to primary active transport). The energy required to drive transport resides in the transmembrane electrochemical gradient of the driving ion.
Secondary active transport is also referred to as ion-coupled transport. Those utilizing Na
+ as the driving ion are called Na
+-coupled transporters. Those utilizing H
+ as the driving ion are called H
+-coupled transporters.
Two types of secondary active transport exist:
cotransport (also known as
symport) and
exchange (also known as
antiport). Na
+/glucose cotransporter and H
+/dipeptide cotransporter are examples of cotransporters. Na
+/Ca
2+ exchanger and Na
+/H
+ exchanger are examples of exchangers.
Related glossary terms/phrases:
CotransportSymportExchangeAntiportSee also:
Lecture notes on
Secondary Active Transport
Posted: Sunday, March 31, 2013
Last updated: Friday, August 28, 2015