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Glossary of Physiology Terms
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There are 3 glossary search results for:   cholinergic




Definition:
Refers to neurons, synapses, or receptors where acetylcholine is used as the neurotransmitter.

For example, cholinergic neurons release acetylcholine as their neurotransmitter.

In cholinergic synapses, acetylcholine is released from the presynaptic neuron, and it acts on acetylcholine receptors in the plasma membrane of the postsynaptic cell.

Cholinergic receptors are those that respond to acetylcholine as the physiological ligand. The two major types are nicotinic and muscarinic cholinergic receptors (may also be referred to as nicotinic and muscarinic acetylcholine receptors).

Cholinergic drugs are compounds that mimic the action of acetylcholine by binding to and activating cholinergic receptors.



Definition:
An enzyme found in the synaptic cleft at cholinergic synapses. It degrades acetylcholine to choline and acetate and, thus, terminates the action of acetylcholine at the synapse. Neither choline nor acetate can bind to acetylcholine receptors (nicotinic or muscarinic).



Definition:
A potent blocker of nicotinic cholinergic receptors (nicotinic acetylcholine receptor, nAChR) found at the neuromuscular junction. At small doses, curare can lead to muscle weakness. At high doses, curare can lead to paralysis of skeletal muscles, which would also result in asphyxiation (and ultimately death) due to paralysis of the diaphragm. Curare was commonly the active agent of poison arrow.

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Posted: Sunday, March 31, 2013
Last updated: Friday, August 28, 2015