Physiology Quiz -
Classical Neurotransmitters - Part 7

Classical neurotransmitters refer to a small group of small molecule neurotransmitters. These neurotransmitters are used by the nervous system in a variety of circuits to transmit information from pre-synaptic neurons to post-synaptic cells. Test your basic knowledge of classical neurotransmitters by taking this simple quiz.

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(1) Post-synaptic GABA_B receptors are:

	(A) Ligand-gated chloride (Cl⁻) channels
	(B) G protein-coupled receptors that, once activated, reduce the activity of potassium (K⁺) channels in the plasma membrane (i.e., decrease in membrane K⁺ conductance).
	(C) G protein-coupled receptors that, once activated, increase the activity of potassium (K⁺) channels in the plasma membrane (i.e., increase in membrane K⁺ conductance).
	(D) G protein-coupled receptors that, once activated, reduce the activity of calcium (Ca²⁺) channels in the plasma membrane (i.e., decrease in membrane Ca²⁺ conductance).
	(E) G protein-coupled receptors that, once activated, increase the activity of calcium (Ca²⁺) channels in the plasma membrane (i.e., increase in membrane Ca²⁺ conductance).

(2) Pre-synaptic GABA_B receptors are:

	(A) Ligand-gated chloride (Cl⁻) channels
	(B) G protein-coupled receptors that, once activated, reduce the activity of potassium (K⁺) channels in the plasma membrane (i.e., decrease in membrane K⁺ conductance).
	(C) G protein-coupled receptors that, once activated, increase the activity of potassium (K⁺) channels in the plasma membrane (i.e., increase in membrane K⁺ conductance).
	(D) G protein-coupled receptors that, once activated, reduce the activity of calcium (Ca²⁺) channels in the plasma membrane (i.e., decrease in membrane Ca²⁺ conductance).
	(E) G protein-coupled receptors that, once activated, increase the activity of calcium (Ca²⁺) channels in the plasma membrane (i.e., increase in membrane Ca²⁺ conductance).

(3) After γ-aminobutyric acid (GABA) is released from the pre-synaptic neuron, GABA diffuses across the synaptic cleft to bind to and activate post-synaptic GABA receptors. Termination of GABA neurotransmission is then brought about:

	(A) by enzymatic breakdown of GABA by extracellular enzymes present in the synaptic cleft.
	(B) by binding of GABA to proteins present in the synaptic cleft.
	(C) by transport of GABA out of the synapse and into the pre-synaptic axon terminal or surrounding glial cells via the activity of GABA transporters (GATs)

(4) Which of the following γ-aminobutyric acid (GABA) receptors are found primarily in retinal circuits?

	(A) GABA_A receptor
	(B) GABA_B receptor
	(C) GABA_C receptor

(5) In GABAergic axon terminals, GABA accumulation into synaptic vesicles is brought about via:

	(A) Na⁺/Cl⁻/GABA cotransport into the vesicle lumen
	(B) H⁺/GABA exchange

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Posted: Monday, March 16, 2015
Last updated: Tuesday, March 11, 2025

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Physiology Quiz -Classical Neurotransmitters - Part 7

Physiology Quiz -
Classical Neurotransmitters - Part 7