A potent blocker of nicotinic cholinergic receptors (nicotinic acetylcholine receptor, nAChR) found at the neuromuscular junction. At small doses, curare can lead to muscle weakness. At high doses, curare can lead to paralysis of skeletal muscles, which would also result in asphyxiation (and ultimately death) due to paralysis of the diaphragm. Curare was commonly the active agent of poison arrow.

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