Proposed model for the inactivation of some voltage-gated ion channels. According to this model, after channel opening, the pore of the open channel is plugged by a globular cytoplasmic portion of the channel protein. The globular portion (ball of amino acids) is tethered to the rest of the protein by a linker part (chain of amino acids).
Concave on both sides of a structure, usually referring to a disc or a lens.
Of particular importance to physiology is the structure of mature red blood cells (erythrocytes), which is a flattened cell that has assume a biconcave shape. It is thought that the biconcave shape of red blood cells helps with the flow property of blood through blood vessels.
The body mass index is measured by dividing body weight (in kilograms) by body height (in meters) squared (kg / m2). It is highly correlated with body composition, and higher BMI values are correlated with higher body fat content. The BMI value is used to classify one's weight in several categories including underweight, normal, overweight, and obese. The range of BMI values considered to be normal is 18.5 to 24.9. Higher BMI values are associated with an increased risk for diseases such as diabetes mellitus type II, hypertension, and cardiovascular disease.